Cat’s coat coloration is a gender-related gene. Color of their fur are control by gene that’s on a chromosome or DNA of each cat. Normally cat had 19 pair of chromosome that separate to be 18 pair for physique chromosome and 1 pairs for gender chromosome. Male cat is has "XY" chromosome type, female cat will have "XX" chromosome type. About reason that we find most cat with Tri-color pattern is female, it causes by gene that control fur’s color attribute was on X chromosome and have 2 alleles. First allele is a strong type gene that calls “
Mostly Tri-color pattern is female cat, but sometimes male too. Especially if cat have some fault on gender chromosome, ex. Gender chromosome is “XXY” [have additional “X” chromosome more than normal] that’s call “Klinefelter’s syndrome” that’s make cat have “X” chromosome about 2 pieces. If gene on both “X” chromosomes have allele type “O/o”. It will make male cat has a Tri-color pattern too. Even cat behavior is look like a male cat, because of effect by “Y” chromosome. However male cat with Tri-color pattern is very rare and hard to find, and mostly was barren.